MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
نویسندگان
چکیده
منابع مشابه
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood. Here, we demonstrate that the full four-helical bundle domain (4HBD) in the N-terminal region of MLKL is required and sufficient to induce its oligomerization and trigger cell death. Moreover, we found t...
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From the Departments of Neuroscience & Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, the Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany, the Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Te...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2014
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2014.04.026